Nothing has gone wrong with it, but I've only had it a short while. However, my history with Honda/Acura products suggests that I will likely not have any problems in the foreseeable future.
I love this car. I'm a little disappointed in the gas mileage so far, but others have told me that it will improve with more miles. The steering on-center feel is a little numb, and the steering effort at freeway speeds is a little higher than I'd like, but overall this is a really nice car. Interior materials are on par with my Acura, fit and finish is fantastic. The engine is powerful and relatively smooth, although not quite as smooth as the 3.2 in my Acura.
The tires are awful. The OEM Michelins are hard riding, noisy, lack grip, don't work in snow well and don't track well. As with my Acura, I will be replacing them soon with a set of Bridgestones. I continue to be mystified as to why Honda insists on using these over-priced, under-performing tires.
I guess the lower-profile Michelins on the V6 don't ride as well as the ones on the EX four-cylinders. Our EX-L has Michelins and they are fabulous! The ones on the 16" wheels ride well, are quiet, and still very grippy!