The Mark Levinson Stereo Subwoofer failed at about 30,000 (but Lexus didn't cover under warranty).
The Mark Levinson Stereo driver & passenger door speakers (6" mid-woofers) just blew - Lexus also not covering it, but Customer Service Support group got Lexus of Clearwater to 'donate' one speaker if I let them install.
The driver's mirror was replaced under warranty.
The battery failed twice in 3 years, but I replaced with Optima and haven't had a problem since.
Front brakes were needed at 25,000 miles which seemed excessive, and the master cylindar was replaced as well under warranty.
The trunk struts (hold the trunk open) have both failed and I don't want to pay $500 to dealer for this item that is a known defect.
Other than that, love the ride, power & luxury, but Lexus could do a better job of honoring problems that they are aware of...
I've found that Mark Levinson stereo speakers for the 2001 Lexus LS430 were not designed to be subjected to extreme combinations of bass and volume.
I had the same problem with my subwoofer after my nephew played some rap music too loud in the stereo. After some research on the internet, I came across a repair that made the subwoofer good as new. Altogether it cost $6 and about an hour of my time.
Much better than replacing with a new speaker, as quoted at $860.
Try a google search for "ls430 subwoofer repair". Good luck.