I've had to replace various engine gaskets due to severe oil leaks, the fast idle servo was replaced to correct a surging problem, the daytime running light module burnt out, the multi-function switch on the steering column broke, the tailgate release latch is really stiff, the hood release cable broke.
Other than that, I have only done routine maintenance and manufacturers suggested service.
This was the first year of the factory installed V8 so it's the 165 hp non-magnum version; good power for a 1/4 ton, but really bad gas mileage. (about 12 city 24 highway)
I've heard of problems with the paint on these trucks, but mine (grey) is still all there and shines like new. The interior still looks new and is well cared for.
Update: the transmission recently started slipping and shifting poorly with around 220,000 KM on the clock. Turns out the last shop to change the fluid never changed the filter or flushed it properly. Oh, and the oil pan gasket is now deteriorating rapidly. At least I won't have to worry about rust on the bottom of the truck. Other problems include the catalytic converter burning out and taking the O2 sensor with it. A new sensor and a piece of straight pipe fixed that. WAY more power now. Sounds great too.