I have replaced 4 plug coils over the years. One of the coils caused the rear cat to burn up, because I drove it with a miss for a while.
ABS problems at 170,000 miles. The brake pads usually lasted around 2 years before they need changing.
CDs will sometimes get stuck in the CD changer, sometimes the door will open to put a disk in and the changer is not in proper position. The CD will get stuck on top of the rack and cause it to malfunction. Sometimes someone will accidentally put 2 disks in one slot. It is easy to remove the player; remove two screws, and remove the stuck CDs.
The interior is quite durable, seats are high quality. They wear well, clean easily and look like new. The material on the side of the doors does not stay attached well. There must have been a defect in the adhesive they used to hold them on. The dash is laid out well, and all buttons and switches work without problems.
This is the original motor and trans in this Escape, with 217,000 miles and counting. I change my oil every 10,000 to 15,000 miles. The trans fluid has never been changed since new.
I have had some tranny issues, like what has been mentioned in other posts, but it has always turned out to be a sensor, or electrical problem that needed to be fixed. If you continue to drive a car with a trans electrical problem, it can cause failure of the trans. Also, I work on the Escape myself, and I can't tell you how many times an auto tech will jump and tell you to replace something major, when really it may be a simple problem. Use common sense, read and learn about how your automobile works, or you will get taken to school and the bank.
I have owned many automobiles; they all break. Toyotas, Hondas, Nissans, Chevy, Ford etc., and some years of models are prone to different problems. The only difference I have seen is that most oversea brands are much more expensive to fix when they do break. Good luck with yours.