I've only had the NSX for 6 weeks, but so far, I'm very happy.
Ergonomics: I'm a little over 6 feet tall and am very comfortable behind the wheel. Could use a little more foot room (I have size 13 feet) but still okay during long rides, thanks to cruise control. There seems to be a bit less leg room on the passenger side though.
Shoulder and arm room are fine. Steering wheel is fully adjustable. My 6' 4" friend is also very comfortable behind the wheel. He has more room in the NSX than does he in his 1993 Mazda RX7.
Performance: The NSX is the first true "Sports" car I've owned so to me, it's fast and handles like it's on rails; however, it's definitely NOT the fastest/quickest or best handling car I've ever driven. Corvettes (newer) handle better and the list goes on about the cars are faster. Although, with 0 - 60mph in just under 5 seconds with no modifications, it's quicker than 99% of the other cars on the road.
Ride: The NSX has the nicest ride out of all the sports cars I've had the privilege to ride/drive in. The NSX has a very well mannered ride for those long distance travels. Spending 6 hours behind the wheel would be no problem.
Creature comforts: The air conditioning works great. The cup holder is pretty much worthless. No power steering on the 91-94 and 99' Zanardi edition NSX's which is fine with me. The front end is light enough that power steering is not really needed, except maybe when parallel parking. There is a small glove box that doesn't hold much.
Styling: Beauty is in the eye of the beholder. The NSX is the sexiest car on the planet. Pretty much every where I go, even at a gas station, people will ask me about the car. Other drivers will ask me questions while stopped at a traffic light, and leave me comments about what an awesome looking car it is. If you don't want to be the center of attention, don't be seen in the NSX.
Other: There is no other car that can deliver styling, performance, comfort, AND reliability like the NSX. By the way, on my last outing, I averaged 26 miles to the gallon. Oh yeah, it's also a low emission vehicle too.