A/C stopped blowing cold air within a month of getting it. Nissan dealer recharged the freon, but it recurred 2yrs later. This time I took it back to the place where I bought it and they fixed the problem properly for free - rear A/C pump and tube leaking.
Display on the radio went after 2 years - seems this is a common problem. Fixed by the vendor for free.
Headlights both went mid-way through a night-time drive from Delaware. A loose wire fixed by the dealer.
This is a good van for the money.
It's considerably quieter than the Windstar we were considering.
It can carry hefty loads with the seats down/removed. However taking the middle row seats out is tiresome, as they are pretty heavy and bulky.
It has a mediocre safety rating, but in the one incident we've had (we got rear-ended by a Mercedes M-class SUV) the Quest had a scratch on the bumper whilst the Merc was quite beat up.
Engine is respectable for a van. It offers reasonable fuel economy, and is good at pulling away from lights.
The Quest's front wheel drive has proven itself capable in 4" of snow, but I wouldn't want to drive it to a really snowy place. If you live someplace that gets a lot of the white stuff you ought to consider the AWD vans out there.
Finally, if you detest Fords, don't buy this van because Ford built it for Nissan. Some components are shared, e.g. the radio is the same as you would get in an Explorer.