The major things I've replaced were the water pump/timing belt (at the same time) and one of the brake lines. That rotted through because Dodge, in their infinite wisdom, put foaming material on the break lines to cushion any rattling, but the moisture trapped in there caused the line to rot. I've had the car for 7 years now and cannot remember anything else that was major - just the usual oxygen sensor, emergency brake cable, and some other relatively minor issues. The headlights on this car are terrible. The low beams work better than the high beams.
I've loved this car from day 1. With 133k miles currently, it still rides beautifully. My wife told me I should get rid of it since the a/c recently quit (compressor), but the body (the car, that is) is in decent shape, and everything else on it works. It is a very comfortable car to drive. The trunk is huge. No major leaks at this time, although is consumes some oil between changes - maybe 1/2 quart, if that. After the tires the dealer put on wore down (Goodyear Eagle LS), I replaced them with Yokohama Avid Touring and they are much quieter. I've got 45k on my current set with lots of tread wear still left.
I forgot to mention the fuel economy on this vehicle. The downside is that the owner's manual recommends 89 octane, which is more expensive than 87, but I can count on 1 hand the number of times I put 87 in it. I found this out after I purchased the vehicle. I drive mainly mixed city-highway driving and with an 18 gallon tank, I get an honest 23 mpg or so. When taking a longer trip on the highway, it gets around 27 mpg - 450 miles on 1 tank. I am impressed with the mpg considering the mileage on the vehicle.