Radiator developed leaks at about 230,000 miles.
Drivers side power window motor has recently died.
Good truck overall. Use the 4x4 all the time, and it's still going strong.
When I was building my house in 1986 one of the contractors, who was a friend of ours, had just bought a new 1986 Ford F-150. He finally traded it last year for a 2009 F-150. He had driven it for over 23 years and had put 365,000+ miles on it. He had had virtually no problems with it. He thinks the new one will be even better, and I'm sure he is right. He'll probably drive it until he dies of old age.