Remarkably little has gone wrong.
Engine light went on at 58,000 - was determined to be a computer 'glitch', had nothing to do with the engine. Cost $300+ to fix at dealership.
Had to replace brake pads at 60,000.
Had to replace tires at 60,000.
Nothing else has gone wrong with the car. I bought it certified from Tri County Lexus Dealers in Totowa, NJ.
They do the maintenance and are extremely fast and reliable. They always provide a loaner car as well.
I don't think I will ever buy another car. I have owned a Honda, Huyndai, Toyota, Audi, Chevy and a Volkswagen Kharman Ghia and Jetta. All of these cars had problems.
Comfortable, luxurious interior.
Feel very safe driving this car.
Only thing I would change- tighter turning radius.
I have had overall good luck with my RX300 45K miles, I agree with someone else comment about the turning radius.